An antimicrobial compound made by honeybees could become the basis for new antibiotics, according to new research at the University of Illinois at Chicago (UIC).
No new antibiotics have been discovered for more than 30 years, and some bacteria are becoming immune to the drugs used to treat or prevent infections. Antibiotic resistance called one of the world’s most pressing public health concerns by the Centers for Disease Control and Prevention, can mean illnesses that were once easily treatable are now potentially deadly.
In a new study published in the journal Nature Structural & Molecular Biology, UIC researchers, led by co-investigators Alexander Mankin and Nora Vazquez-Laslop of the College of Pharmacy’s Center for Biomolecular Sciences, explained how a derivative of the antibiotic apidaecin (Api137) can block the production of proteins in potentially harmful bacteria.
Many antibiotics kill bacteria by targeting the ribosome, which makes all the proteins in the cell. Protein production can be halted by interfering with different stages of translation the process by which DNA is “translated” into protein molecules, Mankin said. Api137 is the first known inhibitor of translation termination, he added.
An antimicrobial compound made by honeybees could become the basis for new antibiotics, according to new research at the University of Illinois at Chicago (UIC).
No new antibiotics have been discovered for more than 30 years, and some bacteria are becoming immune to the drugs used to treat or prevent infections. Antibiotic resistance called one of the world’s most pressing public health concerns by the Centers for Disease Control and Prevention, can mean illnesses that were once easily treatable are now potentially deadly.
In a new study published in the journal Nature Structural & Molecular Biology, UIC researchers, led by co-investigators Alexander Mankin and Nora Vazquez-Laslop of the College of Pharmacy’s Center for Biomolecular Sciences, explained how a derivative of the antibiotic apidaecin (Api137) can block the production of proteins in potentially harmful bacteria.
Many antibiotics kill bacteria by targeting the ribosome, which makes all the proteins in the cell. Protein production can be halted by interfering with different stages of translation the process by which DNA is “translated” into protein molecules, Mankin said. Api137 is the first known inhibitor of translation termination, he added.
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