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Monday, 24 April 2017

PM Modi's push for generic drugs to shift focus to chemists: IPA

NEW DELHI, INDIA: Patients may end up with drugs that "may not be effective at all" if doctors were made to prescribe only generic medicines as indicated by Prime Minister Narendra Modi, according to pharma industry body IPA.
The Indian Pharmaceutical Alliance (IPA) said that due to the nature of the current off-patent medicines market in India if such a step were to be followed, the choice of products will be shifted from doctors to chemists, not patients.
Elaborating on the challenges, IPA secretary general, Dilip G Shah told that India is predominantly a market for off-patent medicines with two types of products –generic and similar.
While generic has established bioequivalence with the originators' products, a similar does not have.
"This difference has a significant impact on the public health. A generic is safe and effective, but a similar may or may not be safe and effective as it has not been tested," Shah said.
Reacting to Modi's remarks that government may bring in a legal framework under which doctors will have to prescribe generic medicines, he said: "The prescribing in the INN (International Nonproprietary Names) – popularly referred to as generic – will enable chemists to substitute products of different manufacturers."
Shah further said the choice of product will be shifted from doctors to chemists, not patients.
"As the patient is unaware of the difference between a generic and a similar product, he/she may end up with products that may not be effective at all," he added.
Recently, while inaugurating a charitable hospital in Surat, ( Gujarat) Modi had said: "We will bring in a legal framework by which if a doctor writes a prescription, he has to write in it that it will be enough for patients to buy generic medicine and he need not buy any other medicine."
IPA represents top Indian drugmakers like Sun Pharma, Dr Reddy's, Lupin, Glenmark, Cipla and Cadila, among others.
Analysts are also of the opinion that there could be some "practical problems" with the announcement.
"If the doctor only prescribes the generic name, it will be left to the chemist to decide which particular brand to push. So, the marketing focus of pharma companies will now have to shift from the doctor to the chemist," said Sarabjit Kour Nangra, vice-president at Angel Broking.
She felt that most pharma experts believe that this change may be feasible in government hospitals but not on a pan-India basis.
The last time when the government had attempted something similar was in 1978, but the idea had to be shelved after the pharma industry challenged the order in court, Nangra added.
"If the step is to be implemented, the pricing pressure on the industry is here to stay. Overall logistics and implementation could be the key," she concluded.
© PTI News
Read More: PM Modi's push for generic drugs to shift focus to chemists: IPA

WorleyParsons bags Biosynthetic Technologies' FEED contract in US

HOUSTON, US: WorleyParsons Limited (WOR) has been awarded a contract by Biosynthetic Technologies (BT) to perform front-end engineering design (FEED) design and engineering services for a new synthetic base oil facility that will commercialise BT’s unique technology converting natural oils into performance base stocks.
The plant will be constructed at a site along the Texas Gulf Coast and will be the first of many similar facilities around the world. BT manufactures a revolutionary new class of biobased synthetic molecules that are made from organic fatty acids found in plant oils.
When used in motor oil, BT’s products showed reduced levels of varnish and received some of the highest cleanliness ratings possible after a 150,000-mile field trial. BT’s efforts have resulted in what is considered a leading technology in the lubricant sector as that industry looks to use more environmentally friendly products.
The use of sustainable products has proven to be particularly tough in performance lubricant applications. However, the excellent viscometric, prolonged stability, and low volatility of BT’s product will allow major oil companies to combine performance and sustainability in their product offerings.
Previously, WorleyParsons performed pre-FEED work for BT which included project scoping and definition, technology scale-up and initial cost estimating. WorleyParsons Houston, TX office has led and directed the work effort.
© Chemical Today News
Read More: WorleyParsons bags Biosynthetic Technologies' FEED contract in US

OCI inaugurates nitrogen fertiliser plant in US

NETHERLANDS: OCI NV (OCI) said that it has opened its wholly-owned subsidiary Iowa Fertiliser Company (IFCo) in Wever in south-east Iowa. Also, the plant officially started production of nitrogen fertiliser products.
The Governor of Iowa Terry Branstad, Lt Governor Kim Reynolds, the Lee County Board of Supervisors and others joined OCI in an event to inaugurate one of the largest private sector construction projects in Iowa’s history and the first world-scale, greenfield nitrogen fertiliser facility built in US in more than 25 years.
IFCo has commenced production and sales. The plant will produce approximately 1.5 to 2 million metric tonnes of nitrogen fertiliser products annually and can alternate between products at short notice, depending on market demand.
At the peak of construction, IFCo employed more than 3,500 workers and currently employs more than 200 full-time positions to operate the plant. Additionally, many more indirect positions will be created.
“The start of production at Iowa Fertiliser Company is a transformative moment for the agricultural industry in US. As one of the most innovative and efficient manufacturing plants in the nation, Iowa Fertiliser is leading the way in providing American farmers with a stable, high-quality and domestic source of nitrogen fertiliser products,” said Nassef Sawiris, CEO of OCI NV.
“In Iowa, we have created a roadmap that attracts new businesses and supports key industries that drive long-term economic growth. At the outset of the Iowa Fertiliser project, the unemployment rate in Lee County was the highest in the state at 8.0 percent. That is why my administration fought so hard to encourage the company to locate its new fertiliser plant in this great community. Today, the county’s unemployment rate is down nearly three points to 5.3 percent, providing a positive and meaningful impact on working families in the area,” added Governor Terry Branstad.
© Worldofchemicals News 
Read More: OCI inaugurates nitrogen fertiliser plant in US

Anti-reflective coatings global analysis and opportunity 2017-2027

An anti-reflective coating is an optical coating that is applied on any lens surface or optical element to reduce the reflection. In a typical imaging system, this improves efficiency as much less light is lost. While the primary benefit is the reduced reflection itself, an anti-reflective coating on something like a pair of spectacles helps make the wearer’s eyes more visible, aiding eye contact, according to a report by Future Market Insights.
It also helps reduce the glint from a covert viewer’s telescopic sight or binoculars. An anti-reflective coating consists of transparent thin films with alternating layers of a contrasting refractive index. The anti-reflective coating market caters to the needs of many companies dealing in eyewear, electronics, automobiles, solar panels and telecommunications. 
Eyewear not expected to cede its share
Eyewear is expected to retain a strong position in the anti-reflective coatings market. This is because a large number of people are anticipated to join the workforce in the years ahead and they may require vision correction. These customers should easily be able to see the difference that light transmitting glasses make in their daily lives.
Anti-reflective coating glasses offer greater comfort by the reduction of painful sunlight glare, elimination of unwanted reflections and adjustment of surrounding contrast levels that improves visibility and provides an easier night driving experience. Anti-reflective coating sprays are also useful in eyewear applications.
Electronics and telecommunications are likely to be the second largest end user in the anti-reflective coatings market. It is predicted to show rapid growth during the forecast period due to a booming demand for smartphones. For a device checked more than a hundred times a day, an anti-reflective glass panel can mean the difference between frustration and satisfaction, especially in bright lights, indoors or in sunlight outdoors. Large screens and ultra-high definition televisions in excess of 50 inches are becoming very popular in developed countries.
These massive, flat display panels would need an anti-reflective coating to enable a pleasurable viewing experience for customers. Anti-reflective coatings also find use in the fabrication of semiconductors during the photolithography stage. They help eliminate the reflections, which further enhances lithography.
A focus on renewable and non-polluting sources of energy is a trend that is seen worldwide in the 21st century. There is a greater realisation that conventional resources will eventually deplete, fuelling the urgency to look for alternative energy sources such as solar panels, windmills, and hydropower. Solar panels should become increasingly important in the days ahead and they will prove to be a steady adopter of anti-reflective coatings.
Governments in a number of countries including the US, UK, France, Germany, China and India are framing policies that offer financial incentives to companies installing solar power systems to counter the energy crisis, global warming and unacceptable levels of pollution. Any light reflected from a solar panel is wasted energy and anti-reflective coatings help deliver better light transmission and reduce light reflection.
The automobile industry is already a massive source of employment in developed countries and production is rapidly expanding in emerging markets such as China, India, Thailand, Mexico and Indonesia. Discerning customers have begun to demand the latest technologies in their vehicles such as GPS navigation systems and intelligent touchscreen infotainment systems compatible with their smartphones.
These screens should ideally be coated with an anti-reflective coating as there would be too much glare otherwise, hampering system use. In addition to this, even the car’s windshield and glass usually have an anti-reflective coating to prevent glare distraction while driving.
Lack of customer awareness and regulations to hamper growth
In spite of all the advantages offered by anti-reflective coating in various industries, usability related issues are likely to raise their ugly head in the coming years. There is a lack of consumer awareness about the benefits offered by anti-reflective coating in a few cases. Some countries have very strict norms concerning raw material use in the manufacture of anti-reflective coating, challenging the anti-reflective coatings market growth in the long run.
Key regions and players
The largest anti-reflective coatings market is presently North America due to a high demand for smartphones, solar panels, spectacles and automobiles in the region. However, the strongest growth is predicted to be in Asia because of improving customer awareness of anti-glare spectacles and electronic displays. Rising energy requirements in these populous countries should increase solar panel sales, thereby boosting the APAC anti-reflective coatings market.
Some of the companies operating in the anti-reflective coatings market include Carl Zeiss, Essilor and Hoya Corporation.
© Chemical Today Magazine
Read More: Anti-reflective coatings global analysis and opportunity 2017-2027

Black phosphorus next wonder material for future electronics

NEW HAVEN, US: Discovered more than 100 years ago, black phosphorus was soon forgotten when there was no seeming use for it. In what may prove to be one of the great comeback stories of electrical engineering, it now stands to play a crucial role in the future of electronic and optoelectronic devices.
A Recent discovery by Yale University research team tells that the material could possibly replace silicon as the primary material for electronics. The team’s research, led by Fengnian Xia, associate professor of engineering and science, is published in the journal Nature Communications.
With silicon as a semiconductor, the quest for ever-smaller electronic devices could soon reach its limit. With a thickness of just a few atomic layers, however, black phosphorus could usher in a new generation of smaller devices, flexible electronics, and faster transistors said the researchers.
That’s due to two key properties. One is that black phosphorus has a higher mobility than silicon — that is, the speed at which it can carry an electrical charge. The other is that it has a bandgap, which gives a material the ability to act as a switch; it can turn on and off in the presence of an electric field and act as a semiconductor. Graphene, another material that has generated great interest in recent years, has a very high mobility, but it has no bandgap.
However, finding a way to control the bandgap of black phosphorus is critical to realising its potential applications. To that end, the researchers have discovered that the material’s bandgap is most controllable at a certain thickness. By applying a vertical electric field to the material at that thickness, the researchers can “tune” the bandgap, essentially shrinking the moderate gap to the point where it nearly closes.
That opens up many potential applications for black phosphorus, such as imaging tools, night vision devices, mid-infrared optical modulators, on-chip spectroscopy tools, and other optoelectronic technologies.
“Before this study, the bandgap of black phosphorus could not be dynamically tuned, limiting its applications in optoelectronics,” said Bingchen Deng, lead author of the study and a PhD student in Xia’s lab.
Finding the optimum thickness took some trial and error. “At first, we tried a 4-nanometer thick sample, and we found the bandgap tuning was not very pronounced,” Deng said.
Deng also noted that having a bandgap that can be controlled means that black phosphorus could potentially be used as a topological insulator, a material with the unusual ability to serve as both an insulator (inside the material) and as a conductor (on its surface). Researchers are particularly interested in topological insulators since they could be key to developing low-power electronics in which electrons at the surface do not suffer from scattering.
Other authors for the paper are professor Judy Cha, Yujun Xie, Cheng Li, Qiushi Guo, and Xiaomu Wang from Yale; professor Li Yang and Vy Tran from Washington University; professor Han Wang from the University of Southern California; professor Steve Koester from the University of Minnesota; Hao Jiang of the University of Massachusetts, Amherst; and He Tian of the University of Southern California.
© Yale University News
Read More: Black phosphorus next wonder material for future electronics

INOX Air Products to build six air separation units in India

LEHIGH VALLEY, US: Air Products and Chemicals Inc said that INOX Air Products Ltd its joint venture (JV) in India, will build six new air separation units (ASU) which will serve the growing on-site and merchant liquid industrial gases market in India. The six plants are scheduled to come onstream during the course of 2018 and 2019.
In building these six new plants, INOX Air Products’ industrial gas market presence in India will continue to grow, and further strengthens the already established leadership position the company has in the merchant industrial gases market in India.
The plants will have a combined capacity of over 1,200 metric tonnes per day of liquid product and will serve a variety of regional markets and industry segments across India such as iron and steel making, glass manufacturing and pharmaceuticals.
“The investment in this capacity will bring a much-needed product into the Indian market. As one of the fastest growing economies in the world, we continue to invest in these projects to ensure that we are in the best position to support the continued growth of the India economy in general, and the manufacturing industry in particular. The positioning of this capacity in key industrial regions will enable us to serve our customers with market leading efficiency and reliability,” said Siddharth Jain, director, INOX-Air Products.
“We are very pleased to be able to announce these investments, totalling over $100 million. We are proud to be able to play our part in making “Make in India” a reality, as efficient and reliable supplies of industrial gases are a key enabler for manufacturing,” added Richard Boocock, president, Air Products industrial gases, Middle East, India, Egypt and Turkey.
© Worldofchemicals News
Read More: INOX Air Products to build six air separation units in India

Avantor acquires cGMP materials supplier in US

CENTER VALLEY, US: Avantor Performance Materials LLC has acquired Puritan Products Inc, a supplier of current good manufacturing practice (cGMP) buffers and solutions for biopharma customers, and high-purity chemistries for research and electronic materials customers.
Avantor is a global supplier of ultra-high purity materials for the life sciences and advanced technology markets. The company provides performance materials and solutions for the production and research needs of approximately 7,900 customers across the biotechnology, pharmaceutical, medical device, diagnostics, aerospace & defence, and semiconductor industries.
Avantor will begin the process of integrating Puritan into the company immediately. Customers will now have access to the J T Baker, Macron Fine Chemicals and Puritan brands of high purity products, as well as Avantor’s other portfolio of brands, including NuSil brand high purity biomaterials and silicone.
“The addition of Puritan is a key next step in our growth plans, as it provides access to new customers in US and Europe, a broader portfolio of high-purity products for the biopharma, research and electronic materials industries, and access to additional capabilities, including new cGMP operations and talented new colleagues,” said Michael Stubblefield, CEO of Avantor.  
“The Puritan business complements Avantor’s platform very well, particularly the focus on quality manufacturing and regulatory compliance – two areas that are critical in the life science industry,” added Stub.
© Worldofchemicals News 
Read More: Avantor acquires cGMP materials supplier in US

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