National University of Singapore (NUS) chemists have developed a light enhanced, nickel catalysed method for carbon-hydrogen (C-H) bond functionalisation in organic molecules.
The replacement of “H” in C–H bonds with other atoms or substituents is one of the most coveted ways to create new and useful molecules. However, while the C-H bond can be found in most organic molecules, it is considered inactive and therefore difficult to functionalise. C-H bond functionalisation refers to the substitution of the hydrogen atom in the C-H bond with another functional group, such as an alkene, alkyne, amine, alcohol, ester, aldehyde, acid, etc.
Prof WU Jie and his research group from the Department of Chemistry, NUS have developed an environmentally friendly process that uses visible light and nickel catalysts to enable the vinylation of ethers and amides via C-H bonds. Their method does not require special chemicals or other additives which might result in the generation of hazardous substances.
Ether and amide chemical groups are present in many pharmaceutically active agents. This new method provides an environmentally friendly way for pharmaceutical companies to produce pharmaceutical products involving the modification of these chemical groups.
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